CT-005 - PREVALENCE, AGE AND SEX DISTRIBUTION OF PATIENTS WITH CHRONIC HEALTH CONDITIONS IN A LARGE HEALTHCARE SYSTEM

N. Gronich¹, W. Saliba², J. Schwartz³; ¹Clalit Health Services, and Rappaport Faculty of Medicine, Technion - Israel Institue of Technology, ²Clalit Health Services, and Technion - Israel Institute of Technology, ³University of California, San Francisco.

Background: Disease prevalence and distribution by patient characteristics data are needed to guide “representative” patient enrollment in clinical trials. Our objective was to provide a current snapshot of disease prevalence and proportions of patients with common chronic conditions by age and sex from a large patient sample.

Methods: Cross-sectional descriptive analysis of all enrollees of Clalit Health Services in Israel – A large primary health care organization, on January 1, 2020.
Prevalence of 26 common chronic conditions and 21 types of malignancies were determined, stratified by 5-year age intervals and by sex. The proportion of each age group was calculated by dividing the number of prevalent cases in the age group by the total number of prevalent cases.

Results: Data from 4,627,183 individuals, 2,274,349 males and 2,352,834 females from newborn to 110 years. Obesity (19%), hypertension (13%), and diabetes mellitus (9%), reflux esophagitis-gastritis-duodenitis (5.5%), thyroid disease (5.3%), asthma (5.1%), ischemic heart disease (4.5%), depression (4.5%), osteoporosis (3.8%), and atopic dermatitis (3.6%) were the ten most prevalent conditions. Prevalence of conditions differed by age (cardiovascular disorders, cancers, thyroid, depression, diabetes, osteoporosis, prostatic hypertrophy, chronic obstructive pulmonary disease, glaucoma, and Parkinson’s disease higher at older ages; asthma, atopic dermatitis higher in children and adolescents, obesity peaking in teen years, schizophrenia peaking in middle age) and by sex (higher prevalence of obesity, depression, glaucoma, hypertension, osteoporosis, rheumatoid arthritis, thyroid disorders, breast and female organ cancers in females; and, chronic obstructive pulmonary disease, diabetes, gout, ischemic heart disease, heart and renal failure, schizophrenia and malignancies of bladder, esophagus, kidney, larynx, liver, melanoma, pharyngeal, prostate, and stomach in males). Proportions of age groups within patients' population varied between conditions (for example: 67% of hypertensives were ≥ 65y, 24% ≥ 80y; 73% with ischemic heart disease were ≥ 65y; 29% ≥ 80y, 59% of diabetics were ≥ 65y, 17% ≥80y).

Conclusion: Prevalence of medical conditions and distributions differ by age and sex and should serve to guide “representative” patient enrollment in clinical trials.