Rawls-Palmer Progress in Medicine Award Lecture

Advancing Clinical Pharmacology with the Science of Hepatic Transporters: Impact on Drug Development and Patient Care

Transport proteins in the liver mediate hepatocyte uptake and excretion of many endogenous and exogenous compounds including bile acids, drugs, and metabolites. Advances in our understanding of the role of hepatic transporters in the disposition, efficacy, and safety of medications will be discussed. Novel approaches coupled with mechanistic modeling and simulation to predict drug-transporter interactions and bile acid-mediated drug-induced liver injury will be highlighted. Many intrinsic and extrinsic factors influence the regulation and function of hepatic transport proteins. Understanding these factors and the mechanisms involved is fundamental to improving the safety and efficacy of drug therapy.

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