Senior Scientific Adviser
Certara UK (Simcyp Division)
Sibylle Neuhoff, PhD, Certara UK ltd (Simcyp division) works in the translational science team as Senior Scientific Advisor in the field of PBPK/PD modelling, oral drug absorption, transport and transporter, metabolism, and toxicity. After qualifying as chemist (Frankfurt am Main, Germany), she received her PhD from the department of pharmacy at the Uppsala University (Sweden).
Sibylle is supervising a team of scientists at Simcyp who extrapolate in vitro data to predict in vivo pharmacokinetics in humans and animals. She is helping to develop and implement models within the Simcyp Simulator, which link the processes of drug discovery and development using simulations in virtual patient populations. She is helping to develop and implement models within the SIVA tool kit for the transport module, which allows modelling of in vitro transport assay data to obtain for instance transporter kinetic data. She is involved in consultancy projects related to application of the Simcyp Simulator within the pharmaceutical industry.
Current research interests include pharmacogenomics of drug-metabolizing enzymes and transporters related to drug disposition and pharmacodynamics, ligand interactions with human metabolising enzymes and transporters, and novel approaches to simulate and/or predict metabolic clearance, metabolic drug-drug interactions, and transporter-related interactions in healthy subjects and patient populations.
Sibylle has taught at more than 50 PBPK workshops on the Simcyp Simulator and SIVA (MIDD, Transporter, FIH, DDI, and Best Practise) and published numerous peer-reviewed journal articles (ORCID 0000-0001-8809-1960). She has given regularly invited talks at national and international meetings and conferences.
Disclosure(s): No financial relationships to disclose
Thursday, March 28, 2024
9:30 AM – 10:30 AM MDT