Associate Director, Pharmacometrics
CSL Behring, King of Prussia, PA, USA
Ankur Sharma obtained his B. Pharm from the University of Rajasthan, Jaipur, India, and his MS in Pharmacology from Rajiv Gandhi Technical University, Bhopal, India. After his MS he worked as a Research Associate in the pre-clinical pharmacology R&D department of Piramal Life Sciences in India. Ankur Sharma has received his Ph.D. in Pharmaceutical Sciences from The University of Oklahoma. He was an ORISE fellow in the US FDA. Later Ankur joined Merck as a Sr. scientist in the Quantitative Pharmacology and Pharmacometrics group. His responsibilities included the projection of human doses from nonclinical data to support FIH study design, the development of population PK/PKPD models for anticancer and inhaled drugs, and the establishment of a PBPK platform for studying the PK of drugs administered ocularly. In his current role in CSL as an Associate Director of Clinical Pharmacology and Pharmacometrics, Ankur is responsible for providing PMX support for immunology and hematology programs across all stages of development along with some hybrid roles as clinical pharmacology support for hematology programs. His work included the translation of nonclinical data to inform FIH dose selection and the development of population PKPD and ER models to inform dose selection for Ph II and III trials. His work domain ranges from informing dose selection utilizing preclinical and clinical data to supporting the regulatory submission work related to protocol writing, inputs to regulatory sections like sections 2.7.2, to responding to regulatory feedback. In addition, he is invested in the development of PMX platform-related modalities within the Clinical Pharmacology & Pharmacometrics group.
He has published his work in The AAPS Journal, PLOS One, Journal of Pharmaceutical Technology and Drug Development, Bioorganic Med Chem Letters, and Chem Pharm Bulletin and has posters at conferences like AAPS, ASCPT, and ACOP along with reviewer and editor duties.